Modulation of Protein Stability in Cancer Therapy

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Immunomodulation for Cancer Immunotherapy: Reference

Under ordinary circumstances, however, the ability of tumor cells to trigger an effective immune response is limited. The nominal poor immunogenicity of tumor cells results in part from their weak expression of MHC antigens, adhesion molecules, and costimulatory signals that could allow complete T-cell activation.

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Tumors may also secrete immunosuppressive molecules, and they often fail to express cytokines that activate local immune responses. These evasive strategies can be overcome by introducing molecules or genes for immune modulation into the cancer immunotherapy.

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These immune modulation molecules always contain cytokines and immune checkpoints. Immune modulation for cancer immunotherapy: Cytokines Cytokines are molecules made by some immune system cells.

They are crucial in controlling the growth and activity of other immune system cells and blood cells. Cytokines are injected, either under the skin, into a muscle, or into a vein.

Table of contents

The most common ones are used in cancer immunotherapy are: 1 Interleukins, such as Interleukin-2 IL-2 , which helps immune system cells grow and divide more quickly. A man-made version of IL-2 is approved to treat advanced kidney cancer and metastatic melanoma. It boosts the ability of certain immune cells to attack cancer cells. It may also slow the growth of cancer cells directly, as well as the blood vessels that tumors need to grow.

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The intratumoral injection of adenovirus- or plasmid-encoded XCL1 has been combined with a variety of immunotherapies including adoptive transfer of effector T cells delivery of cytokines such as IL, or IL and DC vaccine. Immune modulation for cancer immunotherapy: Immune checkpoints The co-stimulatory immune checkpoint molecules can enhance the immune response in cancer immunotherapy, like CD40L , enhance cencer immunotherapy by activating or maturing dendritic cells through ligation of CD Buuh, Z. Interrogating the roles of post-translational modifications of non-histone proteins.

Copeland, R. Protein methyltransferase inhibitors as precision cancer therapeutics: a decade of discovery.

“Heat Shock Protein 90 Inhibitors in Oncology” by Dr. Yusaf Tutar

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Modulation of Protein Stability in Cancer Therapy | Kathleen Sakamoto | Springer

Subjects Cancer therapy Methylation. Rent or Buy article Get time limited or full article access on ReadCube. References 1. Article Google Scholar 3. Article Google Scholar 4. Article Google Scholar Download references. Rights and permissions Reprints and Permissions. About this article. Article Tools. Article metrics Citations 0. Altmetric 1. admin